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6 Catechol-O-methyltransferase (COMT) - COMT has an impact on dopamine signaling in the prefrontal cortex, Whilst the association of Met/Val with better gait effectiveness seems being mainly because of the influence of COMT on tonic dopamine regulation from the striatum in Males only. The associations involving COMT, gait and govt functionality were being influenced by gender. The COMT genotype was connected with gait velocity in Males but not in Girls.eight Yet another examine confirmed that PA amounts, by way of dopamine regulation, moderates cognitive and mobility gains by enhancing participation in PA. This system is quite possibly on account of genotypes that happen to be associated with better dopamine operate are connected to better will increase in PA than genotypes related to lower dopamine operate.9

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